| Autor: |
Daisetsu Aoyama, Shigefumi Fukui, Haruhiko Hirata, Keiko Ohta‐Ogo, Hideo Matama, Emi Tateishi, Tatsuya Nishii, Yasuhide Asaumi, Mamoru Toyofuku, Tatsuyoshi Ikeue, Takeshi Ogo, Hatsue Ishibashi‐Ueda, Satoshi Yasuda |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Pulmonary Circulation, Vol 12, Iss 1, Pp n/a-n/a (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2045-8940 |
| DOI: |
10.1002/pul2.12047 |
| Popis: |
Abstract Pulmonary tumor thrombotic microangiopathy (PTTM) is a rapidly progressive subtype of pulmonary hypertension (PH) associated with impaired right ventricular adaptation and very poor prognosis in cancer, and its rapid progression makes antemortem diagnosis and treatment extremely difficult. We describe the case of a 35‐year‐old woman who developed severe PH with subsequent circulatory collapse. The patient was clinically diagnosed with PTTM induced by lung adenocarcinoma harboring the c‐ros oncogene 1 (ROS1) rearrangement within 1–2 weeks, while hemodynamics were stabilized by rescue venoarterial extracorporeal membrane oxygenation support. Crizotinib, an oral tyrosine kinase inhibitor targeting anaplastic lymphoma kinase, MET, and ROS1 kinase domains dramatically resolved PH, resulting in more than 3 years of survival. Targeted gene‐tailored therapy with mechanical support can improve survival in PTTM. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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