Circulating tumor cells as a prognostic biomarker in patients with hepatocellular carcinoma

Autor: Thaninee Prasoppokakorn, Areeya Buntho, Praewphan Ingrungruanglert, Thodsawit Tiyarattanachai, Tassanan Jaihan, Kittipat Kulkraisri, Darlene Ariyaskul, Chonlada Phathong, Nipan Israsena, Rungsun Rerknimitr, Sombat Treeprasertsuk, Roongruedee Chaiteerakij
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-022-21888-9
Popis: Abstract Circulating tumor cells (CTCs) have been shown as a surrogate for cancer progression and prognostication. We aimed to determine an association between CTCs and survival of hepatocellular carcinoma (HCC) patients. Peripheral blood was obtained from 73 HCC patients to enumerate for epithelial CTCs/8 mL blood. CTCs were detected by immunoaffinity-based method using epithelial cell adhesion molecule (EpCAM) and mucin1 (MUC1). The CTCs detection rates of BCLC stages A, B, and C patients were 65.4% (17/26), 77.3% (17/22), and 96% (24/25), respectively, p = 0.018. Patients with CTCs 36 vs. 4.6 months, p
Databáze: Directory of Open Access Journals
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