Human γδ T Cells Augment Antigen Presentation in Listeria Monocytogenes Infection

Autor: Yuli Zhu, Huaishan Wang, Yi Xu, Yu Hu, Hui Chen, Lianxian Cui, Jianmin Zhang, Wei He
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Molecular Medicine, Vol 22, Iss 1, Pp 737-746 (2016)
Druh dokumentu: article
ISSN: 1076-1551
1528-3658
DOI: 10.2119/molmed.2015.00214
Popis: Abstract Circulating γδ T cells In healthy Individuals rapidly respond to bacterial and viral pathogens. Many studies have demonstrated that γδ T cells are activated and expanded by Listeria monocytogenes (L. monocytogenes), a foodborne bacterial pathogen with high fatality rates. However, the roles of γδ T cells during L. monocytogenes infection are not clear. In the present study, we characterized the morphological characteristics of phagocytosis in γδ T cells after L. monocytogenes infection using transmission electron microscopy. Results show activation markers including human leucocyte antigen DR (HLA-DR) and lymph node-homing receptor CCR7 on γδ T cells were upregulated after stimulation via L. monocytogenes. Significant proliferation and differentiation of primary αβ T cells was also observed after coculture of peripheral blood mononuclear cells with γδ T cells anteriorly stimulated by L. monocytogenes. L. monocytogenes infection decreased the percentage of γδ T cells in mouse intraepithelial lymphocytes (IELs) and increased MHC-II expression on the surface of γδ T cells in vivo. Our findings shed light on antigen presentation of γδ T cells during L. monocytogenes infection.
Databáze: Directory of Open Access Journals
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