Phenotypic profile of pulmonary aspergillosis and associated cellular immunity among people living with human immunodeficiency virus in Maiduguri, Nigeria
| Autor: | Idris Abdullahi Nasir, Halima Ali Shuwa, Anthony Uchenna Emeribe, Hafeez Aderinsayo Adekola, Amos Dangana |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Tzu-Chi Medical Journal, Vol 31, Iss 3, Pp 149-153 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1016-3190 2223-8956 |
| DOI: | 10.4103/tcmj.tcmj_46_18 |
| Popis: | Objective: Aspergillus causes many forms of pulmonary infectious diseases ranging from colonization (noninvasive) to invasive aspergillosis. This largely depends on the underlying host's lung health and immune status. Pulmonary aspergillosis (PA), especially the invasive form, occurs as opportunistic to human immunodeficiency virus (HIV) as a result of cluster of differentiation (CD)4+ lymphopenia. The majority of patients with comorbid HIV and aspergillosis go undiagnosed. This study aimed to isolate, identify the etiologies, and determine the prevalence of PA among HIV-infected persons with a productive cough (at least 350 cells/mL (2, 3.2%). The Chi-square test showed a significant association between the prevalence of PA and the CD4+ cell count, age, and gender (P < 0.05) but not with occupation or education level (P > 0.05). Conclusion: The findings from this study indicate that Aspergillus spp. is a significant etiology of acute productive cough in people living with HIV and this is related to the CD4+ cell count of coinfected persons. |
| Databáze: | Directory of Open Access Journals |
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