Prepregnancy body mass index and other risk factors for early-onset and late-onset haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome: a population-based retrospective cohort study in British Columbia, Canada

Autor: Neda Razaz, Sarka Lisonkova, K S Joseph, Giulia M Muraca, Jeffrey N Bone, Li Qing Wang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMJ Open, Vol 14, Iss 3 (2024)
Druh dokumentu: article
ISSN: 2044-6055
DOI: 10.1136/bmjopen-2023-079131
Popis: Background Obesity increases risk of pre-eclampsia, but the association with haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome is understudied.Objective To examine the association between prepregnancy body mass index (BMI) and HELLP syndrome, including early-onset versus late-onset disease.Study design A retrospective cohort study using population-based data.Setting British Columbia, Canada, 2008/2009–2019/2020.Population All pregnancies resulting in live births or stillbirths at ≥20 weeks’ gestation.Methods BMI categories (kg/m2) included underweight (
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