| Autor: |
Melissa Hershman, Karen Torbjornsen, Daniel Pang, Brooke Wyatt, Douglas T. Dieterich, Ponni V. Perumalswami, Andrea D. Branch, Amreen M. Dinani |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Obesity Science & Practice, Vol 9, Iss 3, Pp 218-225 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2055-2238 |
| DOI: |
10.1002/osp4.637 |
| Popis: |
Abstract Objective The Diabetes Prevention Program (DPP) is the gold standard lifestyle modification program that reduces incident type 2 diabetes mellitus. Patients with prediabetes and patients with non‐alcoholic fatty liver disease (NAFLD) often share metabolic features; we hypothesized that the DPP could be adapted and used to improve outcomes in patients with NAFLD. Methods NAFLD patients were recruited into a 1 year modified DPP. Demographics, medical comorbidities, and clinical laboratory values were collected at baseline, 6 and 12 months. The primary endpoint was change in weight at 12 months. Secondary endpoints were changes in hepatic steatosis, metabolic comorbidities, and liver enzymes (per‐protocol basis) and retention at 6 and 12 months. Results Fourteen NAFLD patients enrolled; three dropped out before 6 months. From baseline to 12 months, hepatic steatosis (p = 0.03), alanine aminotransferase (p = 0.02), aspartate aminotransferase (p = 0.02), high‐density lipoprotein (p = 0.01) and NAFLD fibrosis score (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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