| Autor: |
A. Moreno-Estébanez, A. Marinas, I. Garamendi Ruiz, A. González Eizaguirre, N. Reurich-Gómez, S. Boyero Durán, M.M. Mendibe Bilbao, A. Rodríguez-Antigüedad |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Neurology Perspectives, Vol 4, Iss 1, Pp 100144- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2667-0496 |
| DOI: |
10.1016/j.neurop.2023.100144 |
| Popis: |
Purpose: To analyse cases with suspected autoimmune-associated epilepsy (AAEp) and to compare them to patients with acute symptomatic seizures secondary to autoimmune encephalitis (ASS-AEn). Methods: Single-centre retrospective analysis of patients with suspected AAEp seen in an outpatient epilepsy clinic between 2014 and 2021. Differences according to autoimmune testing results and their responsiveness to immunotherapy were assessed and compared with our cohort of patients with ASS-AEn. Results: A total of 30 patients were included: 18 women (60%); mean age 28.2 years at seizure-onset. AAEp was diagnosed in 14 (46.6%), on the basis of antineuronal antibodies, CSF pleocytosis/OCB (oligoclonal bands), MRI with neuroinflammation, and/or PET hypermetabolism. Thirteen patients (43.3%) received immunotherapy, of whom 5 responded (38.4%). Delay between epilepsy-onset and autoimmune testing was longer in patients with negative autoimmune-testing and in non-responders. Viral prodrome (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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