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Santosh Dhakal,1,2 Xingguo Cheng,3 John Salcido,3 Sankar Renu,1,2 Kathy Bondra,1,2 Yashavantha Shaan Lakshmanappa,1,2 Christina Misch,1,2 Shristi Ghimire,1,2 Ninoshkaly Feliciano-Ruiz,1,2 Bradley Hogshead,1,2 Steven Krakowka,4 Kenneth Carson,3 Joseph McDonough,3 Chang Won Lee,1,2 Gourapura J Renukaradhya1,2 1Food Animal Health Research Program, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USA; 2Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA; 3Pharmaceuticals and Bioengineering Department, Chemistry and Chemical Engineering Division, Southwest Research Institute, San Antonio, TX 78238-0510, USA; 4The Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA Background: Influenza (flu) is a constant threat to humans and animals, and vaccination is one of the most effective ways to mitigate the disease. Due to incomplete protection induced by current flu vaccines, development of novel flu vaccine candidates is warranted to achieve greater efficacy against constantly evolving flu viruses. Methods: In the present study, we used liposome nanoparticle ( |
