Prostate Cancer and the Mevalonate Pathway

Autor: Patricia Guerrero-Ochoa, Sergio Rodríguez-Zapater, Alberto Anel, Luis Mariano Esteban, Alejandro Camón-Fernández, Raquel Espilez-Ortiz, María Jesús Gil-Sanz, Ángel Borque-Fernando
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: International Journal of Molecular Sciences, Vol 25, Iss 4, p 2152 (2024)
Druh dokumentu: article
ISSN: 1422-0067
1661-6596
DOI: 10.3390/ijms25042152
Popis: Antineoplastic therapies for prostate cancer (PCa) have traditionally centered around the androgen receptor (AR) pathway, which has demonstrated a significant role in oncogenesis. Nevertheless, it is becoming progressively apparent that therapeutic strategies must diversify their focus due to the emergence of resistance mechanisms that the tumor employs when subjected to monomolecular treatments. This review illustrates how the dysregulation of the lipid metabolic pathway constitutes a survival strategy adopted by tumors to evade eradication efforts. Integrating this aspect into oncological management could prove valuable in combating PCa.
Databáze: Directory of Open Access Journals
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