Dosimetric comparison of two type's applicator geometry in the three-dimensional computed tomography image-based intracavitary brachytherapy treatment planning of carcinoma uterine cervix

Autor: Veenita Yogi, Sanjay Singh Chandel, Suresh Yadav, Om Prakash Singh, Brijesh Goswami, Gopa Ghosh, Suryanshu Choudhary
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Radiation and Cancer Research, Vol 12, Iss 1, Pp 1-9 (2021)
Druh dokumentu: article
ISSN: 2588-9273
2468-9203
DOI: 10.4103/jrcr.jrcr_71_20
Popis: Background: The swift dose fall-off traits with distance from the applicators are the dominant advantage of brachytherapy. The differences in applicator designs will produce different dose distributions in intracavitary brachytherapy (ICBT) applications. Aim: The present study was aimed to find out the dosimetric differences for two type's applicators geometry in ICBT applications for carcinoma uterine cervix (Ca-Cx) performing three-dimensional computed tomography (3D-CT) image-based planning as per recent guidelines from the International Commission on Radiation Units and Measurements report-89. Materials and Methods: Retrospectively, 15 patients of Ca-Cx who have received ICBT treatment based on the 3D-CT image during 1st and 2nd fractions using fixed-geometry and flexible-geometry applicators respectively were selected for this study. For comparison of two type's applicators geometry the dose-volume parameters D100% and D90% of high-risk clinical target volume (HR-CTV), V400%, V200%, V150%, V100%, V50% (volume enclosing 400%, 200%, 150%, 100%, and 50% isodoseline of prescribed dose around target, respectively), and average point “A” dose were evaluated for target. While for organs at risk (bladder, rectum, and sigmoid colon) the dose-volume parameters D2cc, D1cc, and D0.1cc were recorded and evaluated. Results: Fixed-geometry applicator produces significantly lesser HR-CTV volume (P = 0.016
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