Short-Term Effect of Cigarette Smoke on Exhaled Volatile Organic Compounds Profile Analyzed by an Electronic Nose

Autor: Silvano Dragonieri, Vitaliano Nicola Quaranta, Enrico Buonamico, Claudia Battisti, Teresa Ranieri, Pierluigi Carratu, Giovanna Elisiana Carpagnano
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Biosensors, Vol 12, Iss 7, p 520 (2022)
Druh dokumentu: article
ISSN: 2079-6374
DOI: 10.3390/bios12070520
Popis: Breath analysis using an electronic nose (e-nose) is an innovative tool for exhaled volatile organic compound (VOC) analysis, which has shown potential in several respiratory and systemic diseases. It is still unclear whether cigarette smoking can be considered a confounder when analyzing the VOC-profile. We aimed to assess whether an e-nose can discriminate exhaled breath before and after smoking at different time periods. We enrolled 24 healthy smokers and collected their exhaled breath as follows: (a) before smoking, (b) within 5 min after smoking, (c) within 30 min after smoking, and (d) within 60 min after smoking. Exhaled breath was collected by a previously validated method and analyzed by an e-nose (Cyranose 320). By principal component analysis, significant variations in the exhaled VOC profile were shown for principal component 1 and 2 before and after smoking. Significance was higher 30 and 60 min after smoking than 5 min after (p < 0.01 and
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