| Autor: |
Jéssica Natuline Ianof, Francisco José Fraga, Leonardo Alves Ferreira, Renato Teodoro Ramos, José Luiz Carlos Demario, Regina Baratho, Luís Fernando Hindi Basile, Ricardo Nitrini, Renato Anghinah |
| Jazyk: |
angličtina |
| Předmět: |
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| Zdroj: |
Dementia & Neuropsychologia, Vol 11, Iss 2, Pp 176-185 |
| Druh dokumentu: |
article |
| ISSN: |
1980-5764 |
| DOI: |
10.1590/1980-57642016dn11-020010 |
| Popis: |
ABSTRACT Alzheimer's disease (AD) is a dementia that affects a large contingent of the elderly population characterized by the presence of neurofibrillary tangles and senile plaques. Traumatic brain injury (TBI) is a non-degenerative injury caused by an external mechanical force. One of the main causes of TBI is diffuse axonal injury (DAI), promoted by acceleration-deceleration mechanisms. Objective: To understand the electroencephalographic differences in functional mechanisms between AD and DAI groups. Methods: The study included 20 subjects with AD, 19 with DAI and 17 healthy adults submitted to high resolution EEG with 128 channels. Cortical sources of EEG rhythms were estimated by exact low-resolution electromagnetic tomography (eLORETA) analysis. Results: The eLORETA analysis showed that, in comparison to the control (CTL) group, the AD group had increased theta activity in the parietal and frontal lobes and decreased alpha 2 activity in the parietal, frontal, limbic and occipital lobes. In comparison to the CTL group, the DAI group had increased theta activity in the limbic, occipital sublobar and temporal areas. Conclusion: The results suggest that individuals with AD and DAI have impairment of electrical activity in areas important for memory and learning. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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