Surface Acoustic Wave Sensor for C-Reactive Protein Detection

Autor: Ming-Jer Jeng, Mukta Sharma, Ying-Chang Li, Yi-Chen Lu, Chia-Yu Yu, Chia-Lung Tsai, Shiang-Fu Huang, Liann-Be Chang, Chao-Sung Lai
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Sensors, Vol 20, Iss 22, p 6640 (2020)
Druh dokumentu: article
ISSN: 20226640
1424-8220
DOI: 10.3390/s20226640
Popis: A surface acoustic wave (SAW) sensor was investigated for its application in C-reactive protein (CRP) detection. Piezoelectric lithium niobate (LiNbO3) substrates were used to study their frequency response characteristics in a SAW sensor with a CRP sensing area. After the fabrication of the SAW sensor, the immobilization process was performed for CRP/anti-CRP interaction. The CRP/anti-CRP interaction can be detected as mass variations in the sensing area. These mass variations may produce changes in the amplitude of sensor response. It was clearly observed that a CRP concentration of 0.1 μg/mL can be detected in the proposed SAW sensor. A good fitting linear relationship between the detected insertion loss (amplitude) and the concentrations of CRP from 0.1 μg/mL to 1 mg/mL was obtained. The detected shifts in the amplitude of insertion loss in SAW sensors for different CRP concentrations may be useful in the diagnosis of risk of cardiovascular diseases.
Databáze: Directory of Open Access Journals
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