| Autor: |
Thi Thuy Tien Vo, Tzu-Yu Peng, Thi Hong Nguyen, Trang Ngoc Huyen Bui, Ching-Shuen Wang, Wei-Ju Lee, Yuh-Lien Chen, Yang-Che Wu, I-Ta Lee |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1478-811X |
| DOI: |
10.1186/s12964-024-01726-3 |
| Popis: |
Abstract Copper is a crucial trace element that plays a role in various pathophysiological processes in the human body. Copper also acts as a transition metal involved in redox reactions, contributing to the generation of reactive oxygen species (ROS). Under prolonged and increased ROS levels, oxidative stress occurs, which has been implicated in different types of regulated cell death. The recent discovery of cuproptosis, a copper-dependent regulated cell death pathway that is distinct from other known regulated cell death forms, has raised interest to researchers in the field of cancer therapy. Herein, the present work aims to outline the current understanding of cuproptosis, with an emphasis on its anticancer activities through the interplay with copper-induced oxidative stress, thereby providing new ideas for therapeutic approaches targeting modes of cell death in the future. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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