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Jian Jin, Jie Li, Yonghong Liu, Qingfeng Shi, Bo Zhang, Yanting Ji, Pengfei Hu Thyroid and Breast Surgery Department, Cangzhou Central Hospital, Cangzhou, Hebei, 061000, People’s Republic of ChinaCorrespondence: Jie Li, Thyroid and Breast Surgery Department, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou, Hebei, 061000, People’s Republic of China, Email lijie@hebmu.edu.cnBackground: Breast cancer and thyroid cancer are two prevalent malignancies in women, and a potential association between the two diseases has been suggested.Methods: This retrospective case-control study was conducted involving 97 patients with breast cancer and thyroid cancer (BC-TC group) and 97 age-matched patients with breast cancer alone (BC group). Thyroid hormone levels, including triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH), were analyzed in healthy controls, BC patients, and BC-TC patients.Results: BC-TC patients exhibited a higher rate of estrogen receptor (ER) and progesterone receptor (PR) positivity compared to BC patients. Serum T3 levels were significantly decreased in BC and BC-TC patients compared to healthy controls. However, there was no significant difference in T3 levels between BC and BC-TC patients. Serum TSH levels were significantly higher in BC-TC patients compared to BC patients.Conclusion: ER positivity, PR positivity, and serum TSH levels greater than 4.45 mU/L were independent risk factors for primary thyroid cancer in breast cancer patients.Keywords: breast cancer, thyroid cancer, estrogen receptor, ER |
