Proteomics identifies multiple retinitis pigmentosa associated proteins involved in retinal degeneration in a mouse model bearing a Pde6b mutation

Autor:	Mingzhu Yang, Ruiqi Qiu, Xiuxiu Jin, Shun Yao, Weiping Wang, Jingyang Liu, Guangming Liu, Jinfeng Han, Bo Lei
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Retinitis pigmentosa Pde6b mutation Mouse retina Protein proteomics Phototransduction pathways Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-72821-1
Popis:	Abstract Retinitis pigmentosa (RP) is a progressive and degenerative retinal disease resulting in severe vision loss. RP have been extensively studied for pathogenetic mechanisms and treatments. Yet there is little information about alterations of RP associated proteins in phosphodiesterase 6 beta (Pde6b) mutated model. To explore the roles of RP causing proteins, we performed a label free quantitative mass spectrometry based proteomic analysis in rd10 mouse retinas. 3737 proteins were identified at the degenerative time points in rd10 mice. 222 and 289 differentially expressed proteins (DEPs) (fold change, FC > 2, p
Databáze:	Directory of Open Access Journals
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