INDIVIDUAL APPROACHES TO THE CHOICE OF CHEMOTHERAPY REGIMENS FOR RESPIRATORY TUBERCULOSIS IN CHILDREN EXPOSED TO MULTIPLE DRUG RESISTANT TUBERCULOUS INFECTION
| Autor: | M. F. Gubkina, Yu. Yu. Khokhlova, N. V. Yukhimenko, I. Yu. Petrakova |
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| Jazyk: | ruština |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Туберкулез и болезни лёгких, Vol 94, Iss 9, Pp 24-29 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2075-1230 2542-1506 |
| DOI: | 10.21292/2075-1230-2016-94-9-24-29 |
| Popis: | Goal of the study: to develop individual approaches to the choice of chemotherapy regimens for respiratory tuberculosis in children exposed to multiple drug resistant tuberculous infection. Materials and methods. Totally 39 children (3-12 years old) with tuberculosis of chest lymph nodes or pulmonary tuberculosis. Patients were divided into 3 groups: Group 1 (9 persons) with minimal changes – 3 drugs (ZPASPtо), Group 2 (15 persons) with limited lesions – 4 drugs (ZPtоPASE), Group 3 (15 persons) with disseminated lesions – 5 drugs (ZPASPtоAmFq). Duration of chemotherapy: Group 1 – 9.4 ± 0.7 months; Group 2 – 9.0 ± 1.1 months (administration of 4 drugs during the whole treatment course) and 10.5 ± 0.9 months, (transfer after the intensive phase (3.1 ± 0.7 months) to 3 drugs), Group 3 – 13.4 ± 0.7 months. (Transfer after the intensive phase (4.0 ± 0.4 months) to 4 drugs).Results. Chemotherapy course was assessed assuccessful in all groups. Individual approaches to the choice of chemotherapy regimens oftuberculosis in children exposed to multiple drug resistant tuberculous infection should consider not only the data on drug susceptibility of the infection source but also the dissemination of tuberculous lesions in the child. |
| Databáze: | Directory of Open Access Journals |
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