Distinct therapeutic effects of auraptene and umbelliprenin on TNF-α and IL-17 levels in a murine model of chronic inflammation
| Autor: | Saeid Joveini, Fatemeh Yarmohammadi, Mehrdad Iranshahi, Amin Reza Nikpoor, Vahid Reza Askari, Armin Attaranzadeh, Leila Etemad, Zhila Taherzadeh |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Heliyon, Vol 10, Iss 23, Pp e40731- (2024) |
| Druh dokumentu: | article |
| ISSN: | 2405-8440 45338140 |
| DOI: | 10.1016/j.heliyon.2024.e40731 |
| Popis: | Objective: To compare the anti-arthritic potential of orally administered auraptene (AUR) and umbellliprenin (UMB) in chronic inflammation by exploring the differential effect on regulating TNF-α and IL-17. Methods & materials: Sixty male rats were divided into ten groups, and after confirming chronic inflammation, the treatment groups received AUR or UMB orally for 9 days. On day 16, histopathological changes were evaluated. Altered serum levels of the inflammatory cytokines TNF-α and IL-17 were examined as the underlying mechanisms. Results: Administering AUR orally at 16 mM/kg caused a significant increase in body weight gain compared to the baseline (p |
| Databáze: | Directory of Open Access Journals |
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