Analysis of Cardiovascular Hemodynamic and Autonomic Variables in Individuals with Systemic Arterial Hypertension, Type 2 Diabetes Mellitus, and Parkinson’s Disease: A Comparative Study

Autor: Awassi Yuphiwa Ngomane, Raphael Martins de Abreu, Bianca Fernandes, Isabela Roque Marçal, Guilherme Veiga Guimarães, Emmanuel Gomes Ciolac
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Clinical and Experimental Hypertension, Vol 44, Iss 2, Pp 119-126 (2022)
Druh dokumentu: article
ISSN: 1064-1963
1525-6006
10641963
DOI: 10.1080/10641963.2021.2001480
Popis: Background Systemic arterial hypertension (SAH), type 2 diabetes mellitus (T2DM), and Parkinson’s disease (PD) are highly prevalent chronic diseases that can significantly impact the cardiovascular system. Aim The aim of this study was to compare hemodynamic and autonomic variables at rest in individuals with SAH, T2DM, or PD. Methods Fifty sedentary or insufficiently active individuals (22 men) with SAH (age = 66 ± 5.0 yr), T2DM (age = 52 ± 10 yr) or PD (age = 68 ± 8.0 yr) had their resting blood pressure (BP), arterial stiffness, endothelial function, and heart rate variability (HRV) assessed and compared. Results Systolic and diastolic BP were higher in SAH (130 ± 10 / 80 ± 10 mmHg) than T2DM (110 ± 14 / 75 ± 11 mmHg) and PD, and (123 ± 20 / 70 ± 11 mmHg) respectively. T2DM individuals showed lower arterial stiffness (8.4 ± 1.1 m/s), when compared to SAH (10.3 ± 2.3 m/s) and PD (10.6 ± 3.0 m/s). T2DM had greater resting tachycardia showed by the mean RR (759 ± 79 ms), than SAH (962 ± 169 ms) and PD (976 ± 134 ms), which was accompanied by higher sympathetic modulation (low frequency [LF]: 62 ± 19 nu) and lower parasympathetic modulation (high frequency [HF]: 32 ± 16 nu) when compared to SAH (LF: 40 ± 16 nu; HF: 61 ± 33 nu). No differences among groups were found on non-linear HRV markers and endothelial reactivity indexes. Conclusions Individuals with T2DM showed impaired levels of cardiac autonomic markers when compared to individuals with SAH and PD, despite of having lower levels of BP and arterial stiffness.
Databáze: Directory of Open Access Journals
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