Numb-associated kinases regulate sandfly-borne Toscana virus entry
| Autor: | Yarden Moalem, Rodolfo Katz, Anand G. Subramaniam, Yehonathan Malis, Yakey Yaffe, Nofit Borenstein-Auerbach, Keshet Tadmor, Roey Raved, Ben M. Maoz, Ji Seung Yoo, Yaniv Lustig, Chen Luxenburg, Eran Perlson, Shirit Einav, Ella H. Sklan |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Emerging Microbes and Infections, Vol 13, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 22221751 2222-1751 |
| DOI: | 10.1080/22221751.2024.2382237 |
| Popis: | Sandfly-borne Toscana virus (TOSV) is an enveloped tri-segmented negative single-strand RNA Phlebovirus. It is an emerging virus predominantly endemic in southwestern Europe and Northern Africa. Although TOSV infection is typically asymptomatic or results in mild febrile disease, it is neurovirulent and ranks among the three most common causes of summer meningitis in certain regions. Despite this clinical significance, our understanding of the molecular aspects and host factors regulating phlebovirus infection is limited. This study characterized the early steps of TOSV infection. Our findings reveal that two members of the Numb-associated kinases family of Ser/Thr kinases, namely adaptor-associated kinase 1 (AAK1) and cyclin G-associated kinase (GAK), play a role in regulating the early stages of TOSV entry. FDA-approved inhibitors targeting these kinases demonstrated significant inhibition of TOSV infection. This study suggests that AAK1 and GAK represent druggable targets for inhibiting TOSV infection and, potentially, related Phleboviruses. |
| Databáze: | Directory of Open Access Journals |
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