Protein biomarkers of disease progression in patients with systemic sclerosis associated interstitial lung disease

Autor: Giuliana Cerro-Chiang, Matthew Ayres, Alejandro Rivas, Tahmineh Romero, Sarah J. Parker, Mitra Mastali, David Elashoff, Peter Chen, Jennifer E. Van Eyk, Paul J. Wolters, Francesco Boin, Tanzira Zaman
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-023-35840-y
Popis: Abstract Systemic sclerosis is a rare connective tissue disease; and interstitial lung disease (SSc–ILD) is associated with significant morbidity and mortality. There are no clinical, radiologic features, nor biomarkers that identify the specific time when patients are at risk for progression at which the benefits from treatment outweigh the risks. Our study aimed to identify blood protein biomarkers associated with progression of interstitial lung disease in patients with SSc–ILD using an unbiased, high-throughput approach. We classified SSc–ILD as progressive or stable based on change in forced vital capacity over 12 months or less. We profiled serum proteins by quantitative mass spectrometry and analyzed the association between protein levels and progression of SSc–ILD via logistic regression. The proteins associated with at a p value of
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje