| Autor: |
Yilong Shan, Sha Tan, Yuge Wang, Kui Li, Lei Zhang, Siyuan Liao, Li Zhou, Zhezhi Deng, Xueqiang Hu, Haiyan Li, Xuejiao Men, Bingjun Zhang, Lisheng Peng, Zhuang Kang, Yan Zou, Zhengqi Lu |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Frontiers in Neurology, Vol 8 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
1664-2295 |
| DOI: |
10.3389/fneur.2017.00497 |
| Popis: |
Background and objectiveWhite matter hyperintensities can be easily identified by brain imaging. Juxtacortical small lesion (JCSL) is a special type of white matter lesion, defined as no greater than 5 mm in diameter and adjacent to the cerebral cortex in location. We notice lately that JCSLs alone may be associated to various neurological symptoms. Here, we design the present study to determine the risk factors for JCSLs and their clinical manifestations in patients in our neurology clinic.Methods206 participants suffered from neurological disorders and completed magnetic resonance imaging (MRI) examinations were divided into two groups: patients with JCSLs and patients without lesions on MRI. Meanwhile, 129 age- and sex-matched healthy volunteers were also recruited. Laboratory examinations and the phenotypes and distributions of the symptoms of the three groups were compared.ResultsThe serum levels of apoB and homocysteine (HCY) were independently related to the appearance of JCSLs and HCY level was also associated with the number of JCSLs. Patients with JCSLs might present with headache, insomnia, and/or anxiety/depression, which were related with the anatomical locations of the lesions.ConclusionThese data suggest that JCSLs are symptomatic and might in result fromarteriole atherosclerosis, which should raise our attention. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
