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Background. Determination of noninvasive markers of coronary heart disease (CHD) in patients with and without a history of cardiovascular diseases (CVD) in different age cohorts based on clinical characteristics, results of laboratory and instrumental examination methods. Materials and methods. 57 healthy individuals and 220 patients with coronary heart disease were included. A biochemical blood test was performed to determine glucose, total cholesterol, triglycerides, high and low density lipoprotein cholesterol. Using volumetric sphygmography, the cardio-ankle vascular index (L-/CAVI1), pulse wave propagation velocity (CPV) in arteries of predominantly elastic and muscular type (R/L-PWV and B-PWV), augmentation index, ankle-brachial index (R/L-ABI) were recorded. Results. Patients with CHD were divided into 2 groups: the first included 99 patients with an acute form of CHD without a history of CVD; the second included 121 patients with any form of CHD and/or hypertension in the anamnesis. Then healthy and CHD patients were divided into 3 subgroups: 30–40 (n = 54), 40–50 (n = 117), 50–60 years (n = 106). Deterioration of vascular wall parameters in CHD patients with a history of CVD and without compared with healthy individuals was found in all age cohorts. The most significant differences in arterial rigidity parameters between patients with and without previous CVD were found in the groups of 40–50 and 50–60 years. According to the results of regression analysis, independent factors associated with the development of coronary heart disease were determined: in the subgroup of 30-40 years – R-/L-PWV (β = 0.35), L/-CAVI1 (β = 0.28), R/LABI (β = –0.41); 40-50 years - R–/L-PWV (β = 0.38), L/-CAVI1 (β = 0.34), AI (β = 0.37); 50–60 years – L/-CAVI1 (β = 0.33), AI (β = 0.38), R/L-ABI (β = –0.25). Conclusions. Along with classical factors, the indicators of regional arterial stiffness recorded by volumetric sphygmography are important predictors of coronary artery disease in patients with and without a history of CVD. |
