| Autor: |
Jacob Eifer Moller, Christian Hassager, Pär I Johansson, Lene Holmvang, Ole Kristian Lerche Helgestad, Peter D Mark, Martin Frydland, Timothy Prickett, Jens Peter Goetze |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
BMJ Open, Vol 11, Iss 9 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2044-6055 |
| DOI: |
10.1136/bmjopen-2020-048312 |
| Popis: |
Objective To determine the predictive value of pro-C-type natriuretic peptide (pro-CNP) measurement in plasma sampled on admission from patients presenting with ST-elevation myocardial infarction (STEMI).Design Prospective cohort study.Setting Two University Hospitals in Denmark.Participants 1760 consecutive patients (470 females and 1290 males) with confirmed STEMI.Main outcomes and measures The main outcome was all-cause mortality at 1 year after presentation and the primary measure was pro-CNP concentration in plasma at admission in all patients and longitudinal measurements in a consecutive subgroup of 287 patients. A reference population (n=688) defined cut-off values of increased pro-CNP concentrations.Results In all patients, an increased pro-CNP concentration was associated with a higher all-cause mortality after 1 year (HR 1.6, 95% CI 1.1 to 2.4, Plogrank=0.009) including an interaction of sex (p=0.03). In separate sex-stratified analyses, female patients showed increased all-cause mortality (HR1 year 2.6, 95% CI 1.5 to 4.6), Plogrank |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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