| Autor: |
Shao-Fang Nie, Ling-Feng Zha, Qian Fan, Yu-Hua Liao, Hong-Song Zhang, Qian-Wen Chen, Fan Wang, Ting-Ting Tang, Ni Xia, Cheng-Qi Xu, Jiao-Yue Zhang, Yu-Zhi Lu, Zhi-Peng Zeng, Jiao Jiao, Yuan-Yuan Li, Tian Xie, Wen-Juan Zhang, Dan Wang, Chu-Chu Wang, Jing-Jing Fa, Hong-Bo Xiong, Jian Ye, Qing Yang, Peng-Yun Wang, Sheng-Hua Tian, Qiu-Lun Lv, Qing-Xian Li, Jin Qian, Bin Li, Gang Wu, Yan-Xia Wu, Yan Yang, Xiang-Ping Yang, Yu Hu, Qing K. Wang, Xiang Cheng, Xin Tu |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Frontiers in Immunology, Vol 9 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2018.01775 |
| Popis: |
The thymic stromal lymphopoietin (TSLP)/TSLP receptor (TSLPR) axis is involved in multiple inflammatory immune diseases, including coronary artery disease (CAD). To explore the causal relationship between this axis and CAD, we performed a three-stage case-control association analysis with 3,628 CAD cases and 3,776 controls using common variants in the genes TSLP, interleukin 7 receptor (IL7R), and TSLPR. Three common variants in the TSLP/TSLPR axis were significantly associated with CAD in a Chinese Han population [rs3806933T in TSLP, Padj = 4.35 × 10−5, odds ratio (OR) = 1.18; rs6897932T in IL7R, Padj = 1.13 × 10−7, OR = 1.31; g.19646A>GA in TSLPR, Padj = 2.04 × 10−6, OR = 1.20]. Reporter gene analysis demonstrated that rs3806933 and rs6897932 could influence TSLP and IL7R expression, respectively. Furthermore, the “T” allele of rs3806933 might increase plasma TSLP levels (R2 = 0.175, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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