Home noninvasive ventilation in severe COPD: in whom does it work and how?
| Autor: | Tim Raveling, Judith M. Vonk, Nicholas S. Hill, Peter C. Gay, Ciro Casanova, Enrico Clini, Thomas Köhnlein, Eduardo Márquez-Martin, Tessa Schneeberger, Patrick B. Murphy, Fransien M. Struik, Huib A.M. Kerstjens, Marieke L. Duiverman, Peter J. Wijkstra |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | ERJ Open Research, Vol 10, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2312-0541 23120541 |
| DOI: | 10.1183/23120541.00600-2023 |
| Popis: | Background Not all hypercapnic COPD patients benefit from home noninvasive ventilation (NIV), and mechanisms through which NIV improves clinical outcomes remain uncertain. We aimed to identify “responders” to home NIV, denoted by a beneficial effect of NIV on arterial partial pressure of carbon dioxide (PaCO2), health-related quality of life (HRQoL) and survival, and investigated whether NIV achieves its beneficial effect through an improved PaCO2. Methods We used individual patient data from previous published trials collated for a systematic review. Linear mixed-effect models were conducted to compare the effect of NIV on PaCO2, HRQoL and survival, within subgroups defined by patient and treatment characteristics. Secondly, we conducted a causal mediation analysis to investigate whether the effect of NIV is mediated by a change in PaCO2. Findings Data of 1142 participants from 16 studies were used. Participants treated with lower pressure support ( |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|