Association between pre‐sarcopenia, sarcopenia, and bone mineral density in patients with chronic hepatitis C

Autor: Tatiana Bering, Kiara G.D. Diniz, Marta Paula P. Coelho, Diego A. Vieira, Maria Marta S. Soares, Adriana M. Kakehasi, Maria Isabel T.D. Correia, Rosângela Teixeira, Dulciene M.M. Queiroz, Gifone A. Rocha, Luciana D. Silva
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 2, Pp 255-268 (2018)
Druh dokumentu: article
ISSN: 2190-6009
2190-5991
DOI: 10.1002/jcsm.12269
Popis: Abstract Background Preserved skeletal muscle is essential for the maintenance of healthy bone. Loss of bone mineral density (BMD) and muscle strength, considered a predictor of BMD, have been demonstrated in patients with cirrhosis, but they are poorly studied in chronic hepatitis C (CHC) without cirrhosis. Thus, we aimed to evaluate the prevalence of low BMD and its association with body composition, muscle strength, and nutritional status in CHC. Methods One hundred and four subjects [mean age, 50.5 ± 11.3 years; 75.0% males; 67.3% non‐cirrhotic; and 32.7% with compensated cirrhosis] with CHC, prospectively, underwent scanning of the lean tissue, appendicular skeletal muscle mass (ASM), fat mass, lumbar spine, hip, femoral neck, and whole‐body BMD by dual‐energy X‐ray absorptiometry. Muscle strength was assessed by dynamometry. Sarcopenia was defined by the presence of both low, ASM/height2 (ASMI) and low muscle strength according to the European Working Group on Sarcopenia in Older People criteria. The cut‐off points for low ASMI and low muscle strength, for women and men, were 50 years, the T‐score of osteopenia is between −1.0 and −2.49 standard deviation (SD) below the young average value and of osteoporosis is ≥−2.5 SD below the young normal mean for men, and the Z‐score of low bone mass is ≤−2.0 SD below the expected range in men aged
Databáze: Directory of Open Access Journals
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