Hyperbaric oxygenation of autoimmune manifestation in coversational disorders
| Autor: | D. Labunskiy, S. Kiryukhina, V. Podsevatkin, E. Govsh, V. Kolmyykov |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | European Psychiatry, Vol 64, Pp S147-S148 (2021) |
| Druh dokumentu: | article |
| ISSN: | 0924-9338 1778-3585 |
| DOI: | 10.1192/j.eurpsy.2021.404 |
| Popis: | Introduction Study of conversion disorders is urgent problem in psychiatry due to high prevalence of hysterical manifestations, both in structure of various mental diseases and in general somatic network: among population it is from 0.5 to 2%. Objectives Our aim was to study the effect of complex therapy, combining traditional psychopharmacological drugs and hyperbaric oxygenation, on indicators of acid-base balance of blood, neurotransmitter metabolism, immune and hormonal status in experimental modeling of stress, as well as reduction of psychopathological symptoms in various forms of hysterical disorders. Methods Studies were conducted with the participation of 160 patients (145 women and 15 men), average age 33.5 ± 6.1 years, Сontent of adrenaline, norepinephrine, dopamine, serotonin was determined by concentration of prolactin, thyroid-stimulating hormone (TSH), free thyroxine (T4 light), cortisol using ELISA. Immune status was assessed according to following indicators: determination of level of immunoglobulins of classes A, M and G by the method of radial immunodiffusion in a gel; study of total complementary activity of blood serum by hemolytic method. Results It is necessary to highlight a significant increase in the concentration of Ig G and Ig A, a higher level of large, medium and small circulating immune complexes, which does not exclude the development of autoimmune reactions as a result of a long course of the mental process, which occurs with damage to the own cells of the nervous tissue. Conclusions Кevealed changes in the immune and endocrine reactions upon admission, under the influence of HBO treatment indicate involvement of these structures in the pathogenetic mechanisms. Disclosure No significant relationships. |
| Databáze: | Directory of Open Access Journals |
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