| Autor: |
Uta Barbara Metzing, Christian von Loeffelholz, Ricardo Steidl, Bernd Romeike, René Winkler, Falk Rauchfuß, Utz Settmacher, Christian Stoppe, Sina M. Coldewey, Claudia Weinmann, Martin O. Weickert, Ralf A. Claus, Andreas L. Birkenfeld, Christian Kosan, Paul Horn |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-021-04517-9 |
| Popis: |
Abstract We provide a descriptive characterization of the unfolded protein response (UPR) in skeletal muscle of human patients with peritoneal sepsis and a sepsis model of C57BL/6J mice. Patients undergoing open surgery were included in a cross-sectional study and blood and skeletal muscle samples were taken. Key markers of the UPR and cluster of differentiation 68 (CD68) as surrogate of inflammatory injury were evaluated by real-time PCR and histochemical staining. CD68 mRNA increased with sepsis in skeletal muscle of patients and animals (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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