Genome Characterization of Yellow Fever Virus Wild-Type Strain Asibi, Parent to Live-Attenuated 17D Vaccine, from Three Different Sources

Autor:	Emily H. Davis, Jill K. Thompson, Steven G. Widen, Alan D. T. Barrett
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	yellow fever 17D vaccine wild-type virus Asibi sequencing consensus compare Microbiology QR1-502
Zdroj:	Viruses, Vol 13, Iss 7, p 1383 (2021)
Druh dokumentu:	article
ISSN:	1999-4915
DOI:	10.3390/v13071383
Popis:	The yellow fever virus vaccine, 17D, was derived through the serial passage of the wild-type (WT) strain Asibi virus in mouse and chicken tissue. Since its derivation, the mechanism of attenuation of 17D virus has been investigated using three 17D substrains and WT Asibi virus. Although all three substrains of 17D have been sequenced, only one isolate of Asibi has been examined genetically and all interpretation of attenuation is based on this one isolate. Here, we sequenced the genome of Asibi virus from three different laboratories and show that the WT strain is genetically homogenous at the amino acids that distinguish Asibi from 17D vaccine virus.
Databáze:	Directory of Open Access Journals
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