Antioxidative Effects of Nano-curcumin on Liver Mitochondria Function in Paraquat-induced Oxidative Stress
| Autor: | Saba Nikdad, Hassan Ghasemi, Nejat Khiripour, Akram Ranjbar |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Research in Molecular Medicine, Vol 8, Iss 1, Pp 37-42 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2322-1348 2322-133X |
| Popis: | Background: Paraquat (PQ), as the most widely used herbicide in agriculture, induces poisoning in humans and animals mainly through oxidative stress. This study aimed to investigate the protective effects of nano-curcumin compared with curcumin against PQ-induced mitochondrial dysfunction. Materials and Methods: Thirty-six Wistar rats were used in this study. They were separated into 6 groups: control subjects and animals poisoned with PQ that received treatment with or without curcumin and nano-curcumin for 7 days. Liver mitochondria were isolated, and oxidative stress markers, including Total Antioxidant Capacity (TAC), Lipid Peroxidation (LPO), Catalase (CAT) and Superoxide Dismutase (SOD) activity, as well as viability and mitochondrial membrane potential, were assessed. Results: Poisoning by PQ significantly increased the LPO levels and considerably decreased the TAC, CAT, and SOD activity compared with the control subjects (P |
| Databáze: | Directory of Open Access Journals |
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