Oxygen therapy alternatives in COVID-19: From classical to nanomedicine

Autor: Luis F.T. Pereira, Camila A. Dallagnol, Tassiana H. Moulepes, Clara Y. Hirota, Pedro Kutsmi, Lucas V. dos Santos, Cleverton L. Pirich, Guilherme F. Picheth
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Heliyon, Vol 9, Iss 4, Pp e15500- (2023)
Druh dokumentu: article
ISSN: 2405-8440
DOI: 10.1016/j.heliyon.2023.e15500
Popis: Around 10–15% of COVID-19 patients affected by the Delta and the Omicron variants exhibit acute respiratory insufficiency and require intensive care unit admission to receive advanced respiratory support. However, the current ventilation methods display several limitations, including lung injury, dysphagia, respiratory muscle atrophy, and hemorrhage. Furthermore, most of the ventilatory techniques currently offered require highly trained professionals and oxygen cylinders, which may attain short supply owing to the high demand and misuse. Therefore, the search for new alternatives for oxygen therapeutics has become extremely important for maintaining gas exchange in patients affected by COVID-19. This review highlights and suggest new alternatives based on micro and nanostructures capable of supplying oxygen and/or enabling hematosis during moderate or acute COVID-19 cases.
Databáze: Directory of Open Access Journals