The Expression and Clinical Significance of Sphingosine Kinase 1 and Vascular Endothelial Growth Factor in Endometrial Carcinoma

Autor: Hong Yu, null Dejizhuoga, Wei Huang, Donglian Wang, null Gamaquzhen, Xiaomin Jia, Hao Feng
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Emergency Medicine International, Vol 2022 (2022)
Druh dokumentu: article
ISSN: 2090-2859
DOI: 10.1155/2022/6716143
Popis: The aim of the study is to investigate the expression of sphingosine kinase 1 (SPHK1) and vascular endothelial growth factor (VEGF) in patients with endometrial carcinoma and its clinical significance. The tissues of 86 cases of patients with endometrial carcinoma and 54 cases of patients with endometrial atypical hyperplasia were collected. The expression of SPHK1 and VEGF in the tissue was detected by immunohistochemistry. The expression of SPHK1 in patients with endometrial carcinoma was compared with the clinicopathological data. Results. 69 cases (82.1%) of endometrial carcinoma were positive for SPHK1, which was higher than 2 cases (3.7%) of endometrial atypical hyperplasia (P
Databáze: Directory of Open Access Journals
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