Informing antimicrobial management in the context of COVID-19: understanding the longitudinal dynamics of C-reactive protein and procalcitonin

Autor:	Damien K. Ming, Ashleigh C. Myall, Bernarnd Hernandez, Andrea Y. Weiße, Robert L. Peach, Mauricio Barahona, Timothy M. Rawson, Alison H. Holmes
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Bacterial co-infection COVID-19 Biomarkers Antimicrobial stewardship Risk stratification Clinical decision-support Infectious and parasitic diseases RC109-216
Zdroj:	BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-7 (2021)
Druh dokumentu:	article
ISSN:	1471-2334 33545413
DOI:	10.1186/s12879-021-06621-7
Popis:	Abstract Background To characterise the longitudinal dynamics of C-reactive protein (CRP) and Procalcitonin (PCT) in a cohort of hospitalised patients with COVID-19 and support antimicrobial decision-making. Methods Longitudinal CRP and PCT concentrations and trajectories of 237 hospitalised patients with COVID-19 were modelled. The dataset comprised of 2,021 data points for CRP and 284 points for PCT. Pairwise comparisons were performed between: (i) those with or without significant bacterial growth from cultures, and (ii) those who survived or died in hospital. Results CRP concentrations were higher over time in COVID-19 patients with positive microbiology (day 9: 236 vs 123 mg/L, p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/8cc97ea33545413e98a599626bbe4f0d Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF