| Autor: |
J. Oh, S. J. Matkovich, A. E. Riek, S. M. Bindom, J. S. Shao, R. D. Head, R. A. Barve, M. S. Sands, G. Carmeliet, P. Osei-Owusu, R. H. Knutsen, H. Zhang, K. J. Blumer, C. G. Nichols, R. P. Mecham, Á Baldán, B. A. Benitez, M. L. Sequeira-Lopez, R. A. Gomez, C. Bernal-Mizrachi |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-020-18538-x |
| Popis: |
Myeloid cells are involved in hypertension, but their exact role in renin-induced hypertension remains unclear. Here the authors show that impaired vitamin D signaling in myeloid cells causes hypertension via macrophage-specific miR-106b-5p secretion, which activates renin production in the kidney. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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