The Worth of Ionized Calcium Levels Calculated by Zeisler, Butler and Hanna Methods in Diagnosis of Hypocalcemia

Autor: Tuba Batur, Halil İbrahim Akbay, Erdem Çokluk
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Van Tıp Dergisi, Vol 29, Iss 3, Pp 309-313 (2022)
Druh dokumentu: article
ISSN: 2587-0351
DOI: 10.5505/vtd.2022.42744
Popis: INTRODUCTION: It was aimed to examine the diagnostic performance of the ionized calcium levels calculated by the Zeisler, Butler and Hanna method on the evaluation of hypocalcemia. METHODS: Whole blood ionized calcium and serum total calcium levels of 500 individuals aged between 20-60 years were retrospectively screened.Individuals were divided into hypoalbuminemia and normoalbuminemia groups according to their serum albumin concentrations.In these groups, the diagnostic performance of total calcium and ionized calcium concentrations calculated by Zeisler,ButlerandHanna methods in terms of hypocalcemia were examined. While determining hypocalcemia, ionized calcium level was accepted as a reference.The difference and correlation between directly measured ionized calcium and calculated ionized calcium were analyzed by Wilcoxon signed ranks and Spearman correlation analysis. RESULTS: The ionized calcium levels calculated by the Zeisler,Butler, Hanna methods were higher than the directly measured ionized calcium level(p0.05). A significant correlation was observed between ionized calcium and calcium levels calculated by the Zeisler and Hanna methods in the normoalbuminemia group,but this correlation was low(p=0.010;r=-0.269,p=0.014;r=-0.254).No correlation was observed between ionized calcium and calcium calculated by Butler's method(p>0.05). DISCUSSION AND CONCLUSION: The results of the study limit the use of the Zeisler,Butler and Hanna methods in estimating ionized calcium.We believe that it would not be reliable to comment on the level of ionized calcium with these methods.
Databáze: Directory of Open Access Journals
Popis
Abstrakt:INTRODUCTION: It was aimed to examine the diagnostic performance of the ionized calcium levels calculated by the Zeisler, Butler and Hanna method on the evaluation of hypocalcemia. METHODS: Whole blood ionized calcium and serum total calcium levels of 500 individuals aged between 20-60 years were retrospectively screened.Individuals were divided into hypoalbuminemia and normoalbuminemia groups according to their serum albumin concentrations.In these groups, the diagnostic performance of total calcium and ionized calcium concentrations calculated by Zeisler,ButlerandHanna methods in terms of hypocalcemia were examined. While determining hypocalcemia, ionized calcium level was accepted as a reference.The difference and correlation between directly measured ionized calcium and calculated ionized calcium were analyzed by Wilcoxon signed ranks and Spearman correlation analysis. RESULTS: The ionized calcium levels calculated by the Zeisler,Butler, Hanna methods were higher than the directly measured ionized calcium level(p0.05). A significant correlation was observed between ionized calcium and calcium levels calculated by the Zeisler and Hanna methods in the normoalbuminemia group,but this correlation was low(p=0.010;r=-0.269,p=0.014;r=-0.254).No correlation was observed between ionized calcium and calcium calculated by Butler's method(p>0.05). DISCUSSION AND CONCLUSION: The results of the study limit the use of the Zeisler,Butler and Hanna methods in estimating ionized calcium.We believe that it would not be reliable to comment on the level of ionized calcium with these methods.
ISSN:25870351
DOI:10.5505/vtd.2022.42744