| Autor: |
Xuefen Yan, Lu Wang, Lingxu Jiang, Yingwan Luo, Peipei Lin, Wenli Yang, Yanling Ren, Liya Ma, Xinping Zhou, Chen Mei, Li Ye, Gaixiang Xu, Weilai Xu, Haiyang Yang, Chenxi Lu, Jie Jin, Hongyan Tong |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Cancer Medicine, Vol 10, Iss 5, Pp 1759-1771 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2045-7634 |
| DOI: |
10.1002/cam4.3786 |
| Popis: |
Abstract Purpose To explore the relevance of cytogenetic or molecular genetic abnormalities to clinical variables, including clinical and laboratory characteristics and prognosis in Chinese patients with myelodysplastic syndromes (MDS). Methods A total of 634 consecutive patients diagnosed with MDS at The First Affiliated Hospital, Zhejiang University School of Medicine from June 2008 to May 2018 were retrospectively included in this study. All patients had evaluable cytogenetic analysis, and 425 patients had MDS‐related mutations sequencing. Results 38.6% of patients displayed abnormal karyotypes. The most common cytogenetic abnormality was +8 (31%). Sole +8 was related to female (p = 0.002), hemoglobin >10 g/dL (p = 0.03), and |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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