Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing

Autor: Vovko Aleša Dular, Vrečer Franc
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Acta Pharmaceutica, Vol 70, Iss 4, Pp 443-463 (2020)
Druh dokumentu: article
ISSN: 1846-9558
DOI: 10.2478/acph-2020-0038
Popis: This article presents an overview of using process analytical technology in monitoring the roller compaction process. In the past two decades, near-infrared spectroscopy, near-infrared spectroscopy coupled with chemical imaging, microwave resonance technology, thermal effusivity and various particle imaging techniques have been used for developing at-, off-, on- and in-line models for predicting critical quality attributes of ribbons and subsequent granules and tablets. The common goal of all these methods is improved process understanding and process control, and thus improved production of high-quality products. This article reviews the work of several researchers in this field, comparing and critically evaluating their achievements.
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