Dissecting Pathogenetic Mechanisms and Therapeutic Strategies in Drosophila Models of Myotonic Dystrophy Type 1

Autor:	Anissa Souidi, Monika Zmojdzian, Krzysztof Jagla
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	DM1 muscular dystrophy animal model Drosophila drug screen genetic screen therapeutic targets Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 19, Iss 12, p 4104 (2018)
Druh dokumentu:	article
ISSN:	1422-0067 19124104
DOI:	10.3390/ijms19124104
Popis:	Myotonic dystrophy type 1 (DM1), the most common cause of adult-onset muscular dystrophy, is autosomal dominant, multisystemic disease with characteristic symptoms including myotonia, heart defects, cataracts and testicular atrophy. DM1 disease is being successfully modelled in Drosophila allowing to identify and validate new pathogenic mechanisms and potential therapeutic strategies. Here we provide an overview of insights gained from fruit fly DM1 models, either: (i) fundamental with particular focus on newly identified gene deregulations and their link with DM1 symptoms; or (ii) applied via genetic modifiers and drug screens to identify promising therapeutic targets.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/8c8a4b4413ec4e89bdf7855a10c56902 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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