Evaluation of Treatment Response in Lupus Nephritis
| Autor: | Anca BOBIRCA, Florin BOBIRCA, Anca FLORESCU, Carmen IORGUS, Radu TINCA, Anca MUSETESCU, Mihai BOJINCA, Ioan ANCUTA |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Modern Medicine, Vol 28, Iss 4, Pp 389-395 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1223-0472 2360-2473 |
| DOI: | 10.31689/rmm.2021.28.4.389 |
| Popis: | Objectives: To evaluate the effectiveness of the treatment reflected by the rate of response to therapy at 6 months and 12 months of follow-up respectively. Methods: We retrospectively analyzed clinical, laboratory data, treatment regimens, the type of response and relapse rate of 51 patients diagnosed with LN between January 2017 and February 2020. Results:47.06% of the patients underwent renal biopsy, classes III and IV being the most common lupus nephritis types (totaling 35.3% of biopsied patients). All induction therapy choices analyzed in the study- CYC, Glucocorticoids (GCs) and MMF- proved effective at reducing the proteinuria of the patients (p=0.001, p=0.012 and p=0,019 respectively. The 12 months evaluation demonstrated an ascending trend of the complete response, starting from 27.45% at 6 months and almost doubling at 1 year (56.86%). Almost half of patients (49.02%) did not relapse, while most of them (27.45%) had only 1 relapse. Analyzing the risk of relapse for each induction drug used, CYC had the highest rate of recurrence (62.07%). The use of MMF as a maintenance drug associated the lowest degree of recurrence. Conclusions: Both CYC and MMF as induction therapy are significantly effective in reducing proteinuria. The complete response was more frequently identified as an endpoint at 12 months of follow-up. |
| Databáze: | Directory of Open Access Journals |
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