Current status of research on the role of fibronectin in the progression of posterior capsular opacification fibrosis

Autor: Wen-Hao Xu, Shu-Hua Lin, Yu-Jie Jia, Jian Zhao, Fa-Li Jia, Wan-Ying Cao, Li-Lan Jiang, Ying-Jun Li
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Guoji Yanke Zazhi, Vol 22, Iss 10, Pp 1630-1633 (2022)
Druh dokumentu: article
ISSN: 1672-5123
DOI: 10.3980/j.issn.1672-5123.2022.10.06
Popis: Posterior cataract opacification(PCO)is the epithelial-mesenchymal transformation(EMT)of residual lens epithelial cells(LECs)after cataract surgery, resulting in opaque scar which is one of the main complications of cataract surgery. A large amount of fibronectin(FN)produced by LECs after cataract surgery binds to a variety of cell surface receptors, matrix components and growth factors to regulate cell behavior. The purpose of this article is to review the literatures on the treatment of PCO targeting fibronectin and provide references for clinical treatment of PCO. In this paper, the research status of fibronectin in PCO in recent years is reviewed.
Databáze: Directory of Open Access Journals