Langerhans cell histiocytosis in an adult patient
| Autor: | A. E. Karamova, V. V. Chikin, L. F. Znamenskaya, M. A. Nefedova, V. A. Mikhina, N. S. Battalova |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Vestnik Dermatologii i Venerologii, Vol 95, Iss 4, Pp 57-66 (2019) |
| Druh dokumentu: | article |
| ISSN: | 0042-4609 2313-6294 |
| DOI: | 10.25208/0042-4609-2019-95-4-57-66 |
| Popis: | Aim: to present a clinical case of a rare dermatosis — Langerhans cell histiocytosis (LCH) in an adult patient.Materials and methods. A clinical and laboratory examination of a 64-year-old woman who had complained of rashes on the skin of the scalp, neck, trunk and lower extremities accompanied by itching was carried out. A histological study of skin biopsy samples from the lesion area, as well as an immunohistochemical study of Langerhans cell markers — langerin and S-100 protein — were performed.Results. Clinical manifestations of the disease, the presence of histiocytic infiltrate in the epidermis and dermis during the histological study and immunohistochemical detection of langerin infiltrate cells and S-100 protein were all consistent with the diagnosis of LCH. The therapy with methotrexate subcutaneously significantly improved the patient’s condition.Conclusion. Verification of the LCH diagnosis requires a histological study of skin biopsy samples and an immunohistochemical study of Langerhans cell markers. The efficacy of methotrexate in the treatment of this disease has been confirmed. |
| Databáze: | Directory of Open Access Journals |
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