| Autor: |
David Y. W. Lee, Lee-Yuan Liu-Chen, Bryan L. Roth, Niels H. Jensen, Wei Xu, Zhong-Ze Ma |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
Molecules, Vol 13, Iss 9, Pp 2303-2312 (2008) |
| Druh dokumentu: |
article |
| ISSN: |
1420-3049 |
| DOI: |
10.3390/molecules13092303 |
| Popis: |
Bioactivity-guided fractionation of Corydalis yanhusuo has resulted in the isolation of eight known isoquinoline alkaloids - tetrahydropalmatine, isocorypalmine, stylopine, corydaline, columbamine, coptisin, 13-methylpalmatine, and dehydrocorybulbine. The tertiary alkaloids were further analyzed by chiral HPLC to determine the ratios of d-and l-isomers. The isolated compounds were screened for their binding affinities at the dopamine D1 receptor. Isocorypalmine had the highest affinity (Ki = 83 nM). The structure-affinity relationships of these alkaloids are discussed. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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