Genetics of «atopic march» syntropy
| Autor: | E. Yu. Bragina, M. B. Freidin, V. P. Puzyrev |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Сибирский научный медицинский журнал, Vol 40, Iss 5, Pp 4-17 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2410-2512 2410-2520 20200501 |
| DOI: | 10.15372/SSMJ20200501 |
| Popis: | The study of the phenomenon of a combination of several diseases at the same time in an individual, actualized in the second half of the 19th century, is being actively analyzed 150 years later using genetic approaches. We present an overview of the results of such studies in relation to allergic diseases, in particular, a special variant, the so-called «atopic march», the sequential development of eczema, allergic rhinitis and asthma («atopic march» syntropy). The data of genetic and epidemiological studies were summarized, the analysis of genome-wide associative studies was carried out, and the role of mutations in the filaggrin gene (FLG) in the development of the «atopic march» syntropy was considered. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|