| Autor: |
Ruiyun Yu, Qiang Gao, Chao Zhang, Haihuan Yang, Xingwei Yao, Yikun Sun, Hongming Ma, Han-Hwa Hu, Dayong Ma |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal of Traditional Chinese Medical Sciences, Vol 10, Iss 4, Pp 502-511 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2095-7548 |
| DOI: |
10.1016/j.jtcms.2023.09.011 |
| Popis: |
Objective: To explore the effect of Xinglou Chengqi decoction (XCD) on the brain-gut axis in mice with acute ischemic stroke. Methods: A cerebral ischemia-reperfusion model identified as phlegm-heat and fu-organ excess pattern was established by reforming the Longa method and based on the diagnostic criteria of traditional Chinese medicine. Sixty specific-pathogen free male C57BL/6 mice were randomly divided into five groups, and 36 antibiotic-treated (ABX) mice were randomly divided into three groups. Cecum norepinephrine (NE) and motilin (MTL) were detected by enzyme-linked immunosorbent assay, cecum tyrosine hydroxylase (TH) protein expression level was detected by immunohistochemistry, Iba-1 and glial fibrillary acidic protein (GFAP) expression levels were detected by immunofluorescence, and serum inflammatory factor contents were detected using the flow multifactor technique. Results: Compared to the sham group, a significant increase in TH expression level was observed in the cecum in the middle cerebral artery occlusion (MCAO) group (P = .015). MTL levels were significantly increased in the MCAO group compared with the sham group (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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