| Autor: |
Guang Yang, Yuzi Li, Lan Cui, Haiying Jiang, Xiang Li, Chunzi Jin, Dehao Jin, Guangxian Zhao, Jiyong Jin, Rui Sun, Limei Piao, Wenhu Xu, Chenghu Fang, Yanna Lei, Kuichang Yuan, Chunhua Xuan, Dazi Ding, Xianwu Cheng |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 11, Iss 9, p e0163027 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0163027 |
| Popis: |
Dipeptidyl peptidase-4 (DPP4) is one of the most potent mammalian serine proteases participated in the pathogenesis of subclinical atherosclerosis. Here we investigated whether the plasma soluble form of DPP4 is associated with the prevalence of coronary artery disease (CAD) with and without diabetes mellitus (DM). A cross-sectional study was conducted of 496 aged 26-81 years with (n = 362) and without (n = 134) CAD. Plasma DPP4 activity, high sensitive C-reactive protein (hs-CRP), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein levels were measured. The coronary atherosclerotic plaques were evaluated by coronary angiography. The CAD patients with (n = 84) and without (n = 278) DM had significantly higher DPP4 levels (11.8 ± 3.1 vs. 6.9 ± 3.5 ng/mL, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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