Bimodal Antimicrobial Surfaces of Phytic Acid–Prussian Blue Nanoparticles–Cationic Polymer Networks

Autor: Xiaodong He, HuaJun Wu, Yan Wang, Yunjie Xiang, Kai Zhang, Xi Rao, En‐Tang Kang, Liqun Xu
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Advanced Science, Vol 10, Iss 16, Pp n/a-n/a (2023)
Druh dokumentu: article
ISSN: 2198-3844
DOI: 10.1002/advs.202300354
Popis: Abstract Surface modification plays a pivotal role in tailoring the functionalities of a solid material. Introduction of antimicrobial function on material surfaces can provide additional protection against life‐threatening bacterial infections. Herein, a simple and universal surface modification method based on surface adhesion and electrostatic interaction of phytic acid (PA) is developed. PA is first functionalized with Prussian blue nanoparticles (PB NPs) via metal chelation and then conjugates with cationic polymers (CPs) through electrostatic interaction. With the aid of surface adherent PA and gravitation effect, the as‐formed PA–PB–CP network aggregates are deposited on the solid materials in a substrate‐independent manner. Synergistic bactericidal effects of “contact‐killing” induced by the CPs and localized photothermal effect caused by the PB NPs endow the substrates with strong antibacterial performance. Membrane integrity, enzymatic activity, and metabolism function of the bacteria are disturbed in contact with the PA–PB–CP coating under near‐infrared (NIR) irradiation. The PA–PB–CP modified biomedical implant surfaces exhibit good biocompatibility and synergistic antibacterial effect under NIR irradiation, and eliminate the adhered bacteria both in vitro and in vivo.
Databáze: Directory of Open Access Journals
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