Assessment of health-related quality of life of children with idiopathic nephrotic syndrome and their caregivers in China

Autor: Xia Wang, Danny Junyi Tan, Lejing Guan, Yifei Shao, Jingjing Wang, Chunyue Feng, Haidong Fu, Huijun Shen, Xiujuan Zhu, Abdul Rafay, Jianhua Mao, Guannan Bai
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Health and Quality of Life Outcomes, Vol 22, Iss 1, Pp 1-13 (2024)
Druh dokumentu: article
ISSN: 1477-7525
DOI: 10.1186/s12955-024-02310-6
Popis: Abstract Aims The primary aim of this study was to characterize the health-related quality of life (HRQoL) and identify the associated factors among children aged 2 to 18 in China diagnosed with idiopathic nephrotic syndrome (INS). Additionally, the study aimed to evaluate the HRQoL and caregiving burden of their caregivers and investigate the correlation between the HRQoL of the children and that of their caregivers. Methods This study recruited 181 children diagnosed with INS from Children’s Hospital, Zhejiang University School of Medicine in China. The proxy-reported PedsQL Generic Core Module (PedsQL™ 4.0 GCM) was used to measure the HRQoL of children, and the EuroQol five-dimensional questionnaire, five-level version (EQ-5D-5L) was applied to measure caregivers’ HRQoL. Differences in scale scores and total scores of PedsQL™ 4.0 GCM were assessed using t-tests and one-way ANOVA. Multivariate linear regression analysis was used to identify the factors associated with children’s HRQoL. Pearson correlation analysis evaluated the correlation between children’s HRQoL and caregiver’s HRQoL. Results HRQoL of Children with INS declines with increasing age, and children aged 5-18 had lower scores in physical functioning, emotional functioning, school functioning, psychosocial health summary score, and total PedsQL™ 4.0 GCM score compared to healthy children. Various factors, including the mother filling out the questionnaire, the father being unemployed, and the use of other medications except for steroids, were associated with worse HRQoL of children (p values
Databáze: Directory of Open Access Journals
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