Evaluation of anxiolytic-like activity of Vitis vinifera juice in mice

Autor:	Muhammad Aslam, Nuzhat Sultana
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Vitis vinifera Anxiety Flavonoids Open field test The light/dark box Therapeutics. Pharmacology RM1-950
Zdroj:	Avicenna Journal of Phytomedicine, Vol 6, Iss 3, Pp 344-350 (2016)
Druh dokumentu:	article
ISSN:	2228-7930 2228-7949
Popis:	Objective: Scientificstudies have shown that Vitis vinifera (V. vinifera) contains flavonoids and stillbenoids. Flavonoids are well known to possess anxiolytic activities. In view of the idea that flavonoids present in V. vinifera could be useful in anxiety, we evaluated anxiolytic-like activity of V. vinifera juice (VVJ). Materials and Methods: Light/dark box and the open field test were used to assess the anxiolytic potential of V. vinifera juice (VVJ). The juice was given orally by gavage at the dose of 4 and 8 mL/kg body weight. Diazepam (1 mg/kg i.p.) was used as the standard drug. Results: It was observed that the juice produced significant and dose dependent increase in the time spent in light cubicle (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/d8c45f9229f6485a93a66f414004c1b0 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF