| Autor: |
Olatomiwa Olukoya, Temidayo Osunronbi, Damilola A. Jesuyajolu, Blossom C. Uwaga, Ayomide Vaughan, Oluwabusayo Aluko, Temitayo O. Ayantayo, Jeremiah O.I. Daniel, Samuel O. David, Habiblah A. Jagunmolu, Alieu Kanu, Ayomide T. Kayode, Tobi N. Olajide, Lewis Thorne |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
World Neurosurgery: X, Vol 22, Iss , Pp 100318- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2590-1397 |
| DOI: |
10.1016/j.wnsx.2024.100318 |
| Popis: |
Introduction: Sarcopenia is associated with worsened outcomes in solid cancers. Temporalis muscle thickness (TMT) has emerged as a measure of sarcopenia. Hence, this study aims to evaluate the relationship between TMT and outcome measures in patients with malignant intra-axial neoplasms. Method: We searched Medline, Embase, Scopus and Cochrane databases for relevant studies. Event ratios with 95% confidence intervals (CI) were analysed using the RevMan 5.4 software. Where meta-analysis was impossible, vote counting was used to determine the effect of TMT on outcomes. The GRADE framework was used to determine the certainty of the evidence. Results: Four outcomes were reported for three conditions across 17 studies involving 4430 patients. Glioblastoma: thicker TMT was protective for overall survival (OS) (HR 0.59; 95% CI 0.46–0.76) (GRADE low), progression free survival (PFS) (HR 0.40; 95% CI 0.26–0.62) (GRADE high), and early discontinuation of treatment (OR 0.408; 95% CI 0.168–0.989) (GRADE high); no association with complications (HR 0.82; 95% CI 0.60–1.10) (GRADE low). Brain Metastases: thicker TMT was protective for OS (HR 0.73; 95% CI 0.67–0.78) (GRADE moderate); no association with PFS (GRADE low). Primary CNS Lymphoma: TMT was protective for overall survival (HR 0.34; 95% CI 0.19–0.60) (GRADE moderate) and progression free survival (HR 0.23; 95% CI 0.09–0.56) (GRADE high). Conclusion: TMT has significant prognostic potential in intra-axial malignant neoplasms, showing a moderate to high certainty for its association with outcomes following GRADE evaluation. This will enable shared decision making between patients and clinicians. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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